RBM23

Across TCGA pan-cancer cohorts, RBM23 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RBM23’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RBM23 RNA is repressed in tumor relative to normal tissue. In most cancer types RBM23 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where RBM23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBM23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.834	<.001	10	view →
KIRC	Male	II,III,IV	−0.500	<.001	8	view →
LIHC	Female	II,III,IV	+0.716	<.001	7	view →
LUAD	All	II,III,IV	−0.298	<.001	7	view →
STAD	All	II,III,IV	+0.466	<.001	6	view →
HNSC	All	All	+0.395	<.001	6	view →
BLCA	All	All	+0.285	.021	6	view →
CHOL	Male	All	+1.220	<.001	5	view →
KICH	All	All	−0.581	<.001	4	view →
ESCA	All	All	+0.477	.010	2	view →
KIRP	Male	All	−0.468	.017	2	view →
UCEC	All	All	−0.443	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RBM23–THCA

Open the THCA breakdown →