RBM22

Across TCGA patient cohorts, RBM22 mutation is significantly associated with the RNA expression of many other genes, with 485 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM22-associated genes across cancer lineages are DAD1, TANGO2, and NR2C2AP. Each is linked with RBM22 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM22-to-partner and partner-to-RBM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAD1 grouped by RBM22-low versus RBM22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM22→partner) and Y-score (partner→RBM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DAD1 →	+0.492	+3.533	.004	.002	3	2
UCEC	TANGO2 →	+0.510	+3.711	.001	<.001	3	2
UCEC	NR2C2AP →	+0.548	+3.592	.002	.001	3	2
UCEC	RN7SL340P →	+0.096	+3.351	.002	.004	3	2
SKCM	KRT89P →	+0.453	+2.600	<.001	<.001	3	2
BRCA	RNU6-543P →	+0.283	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 485 associations by consensus.

DAD1 by RBM22 expression — UCEC

Explore this box plot interactively →