RBM17

Across TCGA cell cohorts, RBM17 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBM17-associated genes across cancer lineages are ACTRT1, FCN2, and CCDC42. Each is linked with RBM17 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBM17-to-partner and partner-to-RBM17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTRT1 grouped by RBM17-low versus RBM17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM17→partner) and Y-score (partner→RBM17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACTRT1 →	+0.014	+4.273	.005	.006	3	1
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CCDC42 →	+0.033	+4.095	.008	.009	3	1
LARGE_INTESTINE	MBD3L2 →	+0.089	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ACTRT1 by RBM17 expression — LARGE_INTESTINE

Explore this box plot interactively →