RBM15B

Across TCGA pan-cancer cohorts, RBM15B Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RBM15B data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RBM15B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RBM15B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, LIHC, and STAD are the cancer types where RBM15B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.139	0.797	<.001	24	view →
LIHC	DFS	Median	All	0.072	0.555	<.001	18	view →
STAD	OS	Median	All	0.105	0.543	.004	15	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	II,III,IV	0.885	0.436	.034	6	view →
ACC	DFS	Median	All	0.209	0.659	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RBM15B–LUSC (DFS)

Open the LUSC breakdown →