RBM15B

Across TCGA patient cohorts, RBM15B mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBM15B-associated genes across cancer lineages are eIF4E, ATM, and 4E-BP1. Each is linked with RBM15B in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM15B-to-partner and partner-to-RBM15B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RBM15B-low versus RBM15B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM15B→partner) and Y-score (partner→RBM15B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.178	+1.643	.006	.003	3	3
UCEC	ATM →	-0.393	-1.893	.005	.014	3	3
UCEC	4E-BP1 →	+0.380	+4.087	<.001	<.001	3	3
UCEC	mTOR_pS2448 →	-0.108	-1.571	.019	.032	3	2
UCEC	PCNA →	+0.216	+1.807	.001	.003	3	2
UCEC	Rad50 →	-0.213	-2.401	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eIF4E by RBM15B expression — UCEC

Explore this box plot interactively →