RBM15B

Across TCGA cell cohorts, RBM15B mutation is significantly associated with the RNA expression of many other genes, with 614 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBM15B-associated genes across cancer lineages are MSTN, MSH4, and GAGE2A. Each is linked with RBM15B in more than 2 cancer types. Because this analysis shows association rather than direction, both RBM15B-to-partner and partner-to-RBM15B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSTN grouped by RBM15B-low versus RBM15B-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBM15B→partner) and Y-score (partner→RBM15B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MSTN →	+0.211	+3.447	<.001	.007	3	2
LARGE_INTESTINE	MSH4 →	+0.255	+2.979	<.001	<.001	2	3
LUNG_NSCLC_LUAD	GAGE2A →	+2.325	+3.860	<.001	.001	3	2
LARGE_INTESTINE	FEM1A →	+0.764	+3.502	<.001	.001	3	2
LARGE_INTESTINE	HPSE →	+1.093	+3.502	.002	.001	3	2
LARGE_INTESTINE	DCAF4L1 →	+0.206	+3.160	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 614 associations by consensus.

MSTN by RBM15B expression — PANCREAS

Explore this box plot interactively →