RBL2

Across TCGA patient cohorts, RBL2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBL2-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and MEK1. Each is linked with RBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBL2-to-partner and partner-to-RBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RBL2-low versus RBL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBL2→partner) and Y-score (partner→RBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.802	+1.945	<.001	.002	3	3
UCEC	EGFR_pY1068 →	-0.209	-1.502	.010	.027	3	2
UCEC	MEK1 →	+0.568	+2.321	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.364	+3.807	<.001	<.001	3	2
UCEC	PDCD4 →	-0.459	-1.999	.002	.008	3	2
UCEC	ATM →	-0.640	-2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by RBL2 expression — UCEC

Explore this box plot interactively →