RBL2

Across TCGA pan-cancer cohorts, RBL2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RBL2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RBL2 RNA is repressed in tumor relative to normal tissue. In most cancer types RBL2 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and LUSC are the cancer types where RBL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.610	<.001	8	view →
LUAD	All	III,IV	−0.657	<.001	7	view →
LUSC	Female	All	−0.735	<.001	6	view →
BRCA	Female	All	−0.418	<.001	6	view →
HNSC	All	All	+0.417	.008	6	view →
UCEC	All	All	−1.215	<.001	4	view →
KIRC	Male	III,IV	−0.423	.007	4	view →
KICH	All	All	−0.546	.019	1	view →
KIRP	Male	All	−0.449	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RBL2–THCA

Open the THCA breakdown →