RBL2

Across TCGA cell cohorts, RBL2 mutation is significantly associated with the mutation status of many other genes, with 2,952 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBL2-associated genes across cancer lineages are PCSK5, KDM4B, and CPS1. Each is linked with RBL2 in more than 5 cancer types. Because this analysis shows association rather than direction, both RBL2-to-partner and partner-to-RBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCSK5 grouped by RBL2-low versus RBL2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBL2→partner) and Y-score (partner→RBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PCSK5 →	+3.684	+3.217	.006	.006	1	6
CNS	KDM4B →	+4.614	+4.614	.006	.006	1	5
LARGE_INTESTINE	CPS1 →	+1.956	+2.501	.002	.002	1	5
BREAST	CLASRP →	+3.510	+3.807	.004	.004	1	5
BREAST	ATAD2B →	+4.095	+4.095	.002	.002	1	5
STOMACH	LATS1 →	+4.807	+4.807	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,952 associations by consensus.

PCSK5 by RBL2 expression — OVARY

Explore this box plot interactively →