RBKS

Across TCGA cell cohorts, RBKS mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RBKS-associated genes across cancer lineages are KRTAP5-11, MYL10, and SCGB3A2. Each is linked with RBKS in more than 1 cancer types. Because this analysis shows association rather than direction, both RBKS-to-partner and partner-to-RBKS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-11 grouped by RBKS-low versus RBKS-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBKS→partner) and Y-score (partner→RBKS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP5-11 →	+0.028	+3.684	<.001	.006	3	1
BLOOD_Leukemia	MYL10 →	+0.018	+4.569	<.001	.003	3	1
BLOOD_Leukemia	SCGB3A2 →	+0.128	+3.922	<.001	.002	3	1
BLOOD_Leukemia	TLX3 →	+2.721	+4.266	<.001	.001	3	1
BLOOD_Leukemia	OR7G3 →	+0.023	+3.969	<.001	.009	3	1
BLOOD_Leukemia	OTOS →	+0.025	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

KRTAP5-11 by RBKS expression — SKIN

Explore this box plot interactively →