RBFOX1

Across TCGA pan-cancer cohorts, RBFOX1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated RBFOX1 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher RBFOX1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RBFOX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

DLBC, COAD, and UCEC are the cancer types where RBFOX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
COAD	OS	Median	III,IV	0.107	0.787	<.001	25	view →
UCEC	DFS	Median	II,III,IV	0.901	0.428	.009	24	view →
BLCA	DFS	Median	All	0.187	0.512	.013	24	view →
BRCA	OS	Median	III,IV	0.524	0.836	.003	18	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	6	view →
LIHC	OS	Median	All	0.098	0.774	.001	6	view →
ESCA	DFS	Median	III,IV	0.205	0.451	.046	3	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →
SKCM	DFS	Median	All	0.553	0.212	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RBFOX1–DLBC (OS)

Open the DLBC breakdown →