RBFOX1

Across TCGA pan-cancer cohorts, RBFOX1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RBFOX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RBFOX1 RNA is repressed in tumor relative to normal tissue. In most cancer types RBFOX1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where RBFOX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBFOX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.318	<.001	12	view →
KIRP	Male	All	−0.300	<.001	11	view →
HNSC	Male	All	−1.004	.001	8	view →
READ	All	All	−0.406	<.001	7	view →
KICH	Male	All	−0.417	<.001	6	view →
UCEC	All	II,III,IV	−0.320	<.001	6	view →
COAD	Male	II,III,IV	−0.260	<.001	5	view →
PRAD	All	All	−0.508	<.001	2	view →
THCA	All	All	+0.498	<.001	2	view →
LUAD	All	All	+0.128	.026	2	view →
CHOL	All	II,III,IV	+0.055	.008	2	view →
LIHC	All	All	+0.005	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RBFOX1–KIRC

Open the KIRC breakdown →