RBFOX1

Across TCGA patient cohorts, RBFOX1 mutation is significantly associated with the RNA expression of many other genes, with 5,959 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBFOX1-associated genes across cancer lineages are ARL6IP1, KIF22, and MIR6864. Each is linked with RBFOX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RBFOX1-to-partner and partner-to-RBFOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARL6IP1 grouped by RBFOX1-low versus RBFOX1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFOX1→partner) and Y-score (partner→RBFOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARL6IP1 →	+0.370	+3.596	.006	.001	3	5
UCEC	KIF22 →	+0.461	+1.496	<.001	<.001	3	5
BRCA	MIR6864 →	+0.572	+2.547	<.001	.004	3	4
COAD	PIMREG →	+0.866	+3.183	<.001	.009	3	4
COAD	SNRPD1 →	+0.462	+3.472	.005	.002	3	4
UCEC	SAAL1 →	+0.577	+2.085	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,959 associations by consensus.

ARL6IP1 by RBFOX1 expression — LUAD

Explore this box plot interactively →