RBFOX1

Across TCGA patient cohorts, RBFOX1 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBFOX1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and PDCD4. Each is linked with RBFOX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RBFOX1-to-partner and partner-to-RBFOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by RBFOX1-low versus RBFOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFOX1→partner) and Y-score (partner→RBFOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.374	+1.710	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.659	+1.710	<.001	<.001	3	4
UCEC	PDCD4 →	-0.496	-1.736	<.001	.005	3	4
UCEC	Caspase-7-cleavedD198 →	+0.434	+1.084	.005	.028	3	4
SKCM	NF-kB-p65_pS536 →	-0.343	-1.415	.004	.009	3	3
SKCM	AR →	+0.095	+2.584	.048	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

4E-BP1 by RBFOX1 expression — UCEC

Explore this box plot interactively →