RBFOX1

Across TCGA cell cohorts, RBFOX1 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RBFOX1-associated genes across cancer lineages are KCNA5, SCGB1C1, and MROH5. Each is linked with RBFOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBFOX1-to-partner and partner-to-RBFOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA5 grouped by RBFOX1-low versus RBFOX1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBFOX1→partner) and Y-score (partner→RBFOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KCNA5 →	+0.099	+4.369	<.001	.008	3	2
SOFT_TISSUE	SCGB1C1 →	+0.055	+4.977	<.001	.002	3	2
SOFT_TISSUE	MROH5 →	+0.032	+5.515	<.001	<.001	3	2
BLOOD_Lymphoma	CYP7A1 →	+0.031	+4.191	<.001	.007	3	2
OVARY	CYP3A43 →	+0.058	+3.473	<.001	.008	3	2
SOFT_TISSUE	OBP2A →	+0.409	+4.369	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

KCNA5 by RBFOX1 expression — SOFT_TISSUE

Explore this box plot interactively →