RBCK1

Across TCGA pan-cancer cohorts, RBCK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RBCK1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RBCK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RBCK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, CCRCC, and UCEC are the cancer types where RBCK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.376	0.896	<.001	45	view →
CCRCC	OS	Quartile	II,III,IV	0.680	1.000	.004	38	view →
UCEC	OS	Tertile	II,III,IV	0.497	1.000	.017	12	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RBCK1–LSCC (DFS)

Open the LSCC breakdown →