RBCK1

Across TCGA pan-cancer cohorts, RBCK1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RBCK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RBCK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RBCK1 is over-expressed in tumor.

KIRC, HNSC, and COAD are the cancer types where RBCK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBCK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.207	<.001	12	view →
HNSC	Male	III,IV	+0.973	<.001	12	view →
COAD	All	IV	+1.574	<.001	11	view →
KIRP	All	III,IV	+1.299	<.001	11	view →
LIHC	Male	III,IV	+1.433	<.001	9	view →
STAD	Male	III,IV	+1.423	<.001	9	view →
THCA	Male	All	+0.264	<.001	7	view →
BRCA	All	III,IV	+0.575	<.001	6	view →
CHOL	Female	All	+2.743	<.001	5	view →
READ	All	All	+0.921	<.001	5	view →
ESCA	All	All	+1.360	<.001	4	view →
BLCA	All	All	+0.460	.010	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RBCK1–KIRC

Open the KIRC breakdown →