RBCK1

Across TCGA cell cohorts, RBCK1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RBCK1-associated genes across cancer lineages are PRL, ST8SIA3, and TMEM132C. Each is linked with RBCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RBCK1-to-partner and partner-to-RBCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRL grouped by RBCK1-low versus RBCK1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBCK1→partner) and Y-score (partner→RBCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRL →	+0.040	+3.836	<.001	.004	3	1
OESOPHAGUS	ST8SIA3 →	+0.033	+3.392	.006	.007	3	1
OESOPHAGUS	TMEM132C →	+0.005	+3.392	<.001	.007	3	1
SKIN	TCP10L2 →	+0.139	+5.415	<.001	.004	3	1
SKIN	CYLC1 →	+0.006	+5.415	.007	.004	3	1
SKIN	OR1P1 →	+0.022	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PRL by RBCK1 expression — OESOPHAGUS

Explore this box plot interactively →