RBBP8

Across TCGA patient cohorts, RBBP8 mutation is significantly associated with the RNA expression of many other genes, with 4,802 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBBP8-associated genes across cancer lineages are CTSLP8, RNU6-502P, and RNU6-560P. Each is linked with RBBP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both RBBP8-to-partner and partner-to-RBBP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTSLP8 grouped by RBBP8-low versus RBBP8-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBBP8→partner) and Y-score (partner→RBBP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CTSLP8 →	+0.333	+3.564	.008	.004	3	3
SKCM	RNU6-502P →	+0.169	+3.186	<.001	.006	3	3
LUAD	RNU6-560P →	+0.600	+5.748	<.001	.001	3	2
CESC	RN7SL25P →	+0.235	+3.567	<.001	.004	3	2
COAD	RNA5SP442 →	+0.638	+4.893	<.001	<.001	3	2
COAD	CYCSP49 →	+0.160	+5.142	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,802 associations by consensus.

CTSLP8 by RBBP8 expression — HNSC

Explore this box plot interactively →