RBBP6

Across TCGA patient cohorts, RBBP6 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBBP6-associated genes across cancer lineages are c-Kit, Caspase-7-cleavedD198, and TFRC. Each is linked with RBBP6 in more than 4 cancer types. Because this analysis shows association rather than direction, both RBBP6-to-partner and partner-to-RBBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by RBBP6-low versus RBBP6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBBP6→partner) and Y-score (partner→RBBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Kit →	-0.483	-1.874	.048	.049	3	5
UCEC	Caspase-7-cleavedD198 →	+0.416	+1.309	.009	.013	3	5
UCEC	TFRC →	+0.452	+1.459	.001	.001	3	3
UCEC	C-Raf →	+0.149	+1.584	<.001	.004	3	3
UCEC	Cyclin-B1 →	+0.488	+1.736	.001	.005	3	3
LUSC	4E-BP1_pT70 →	+0.305	+3.009	.005	.019	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

c-Kit by RBBP6 expression — SKCM

Explore this box plot interactively →