RBBP6

Across TCGA pan-cancer cohorts, RBBP6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RBBP6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RBBP6 RNA is repressed in tumor relative to normal tissue. In most cancer types RBBP6 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and KIRP are the cancer types where RBBP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBBP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.592	<.001	9	view →
LIHC	All	All	+0.411	<.001	7	view →
KIRP	All	II,III,IV	+0.489	.007	6	view →
KIRC	All	All	+0.335	<.001	6	view →
CHOL	Male	All	+1.509	<.001	5	view →
STAD	All	II,III,IV	+0.615	.006	5	view →
UCEC	All	All	−0.449	.015	4	view →
HNSC	All	All	+0.293	.007	4	view →
BRCA	All	II,III,IV	+0.185	.015	4	view →
KICH	All	All	−0.541	.001	3	view →
COAD	Male	All	+0.344	.017	2	view →
ESCA	Female	All	+0.503	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RBBP6–THCA

Open the THCA breakdown →