RBAK

Across TCGA patient cohorts, RBAK mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RBAK-associated genes across cancer lineages are ATM, GAPDH, and eIF4E. Each is linked with RBAK in more than 2 cancer types. Because this analysis shows association rather than direction, both RBAK-to-partner and partner-to-RBAK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RBAK-low versus RBAK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBAK→partner) and Y-score (partner→RBAK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.576	-1.662	<.001	.011	3	3
BLCA	GAPDH →	+0.584	+3.169	.007	.018	3	2
UCEC	eIF4E →	+0.156	+1.807	.036	.025	3	2
UCEC	4E-BP1 →	+0.328	+2.730	<.001	.003	3	2
UCEC	Cyclin-B1 →	+0.694	+3.807	<.001	<.001	3	2
UCEC	FoxM1 →	+0.249	+1.662	.006	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by RBAK expression — UCEC

Explore this box plot interactively →