RBAK

Across TCGA pan-cancer cohorts, RBAK RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RBAK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RBAK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RBAK is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRP, and THCA are the cancer types where RBAK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RBAK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.824	<.001	12	view →
KIRP	All	IV	+1.079	<.001	10	view →
THCA	Male	III,IV	−0.928	<.001	10	view →
BLCA	All	All	+0.851	<.001	10	view →
KIRC	All	All	+0.441	<.001	8	view →
COAD	Male	All	+0.728	<.001	7	view →
LUAD	All	All	+0.440	<.001	6	view →
BRCA	All	II,III,IV	+0.388	<.001	6	view →
CHOL	Male	All	+1.405	<.001	5	view →
LUSC	Male	II,III,IV	+0.834	<.001	5	view →
LIHC	Male	All	+0.540	<.001	5	view →
STAD	All	II,III,IV	+0.677	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RBAK–HNSC

Open the HNSC breakdown →