RBAK

Across TCGA cell cohorts, RBAK mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RBAK-associated genes across cancer lineages are IAPP, LYZL4, and GUCA1A. Each is linked with RBAK in more than 1 cancer types. Because this analysis shows association rather than direction, both RBAK-to-partner and partner-to-RBAK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IAPP grouped by RBAK-low versus RBAK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RBAK→partner) and Y-score (partner→RBAK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IAPP →	+0.333	+3.839	<.001	.001	3	1
LARGE_INTESTINE	LYZL4 →	+0.142	+3.374	.004	.005	3	1
LARGE_INTESTINE	GUCA1A →	+0.041	+2.841	.001	.009	3	1
LUNG_NSCLC_LUAD	MBD3L2 →	+0.130	+5.228	<.001	.005	3	1
LUNG_SCLC	F9 →	+0.027	+4.643	<.001	.004	3	1
LUNG_SCLC	OR1M1 →	+0.012	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

IAPP by RBAK expression — LARGE_INTESTINE

Explore this box plot interactively →