RB1CC1

Across TCGA patient cohorts, RB1CC1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RB1CC1-associated genes across cancer lineages are ATM, IGFBP2, and ACC_pS79. Each is linked with RB1CC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RB1CC1-to-partner and partner-to-RB1CC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RB1CC1-low versus RB1CC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RB1CC1→partner) and Y-score (partner→RB1CC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.388	-1.398	.002	.004	3	5
CESC	IGFBP2 →	-0.601	-3.000	.047	.033	2	4
SKCM	ACC_pS79 →	+0.288	+3.459	.026	.005	3	3
COAD	ASNS →	+0.487	+2.815	.025	.036	3	3
UCEC	ERK2 →	+0.140	+1.054	.010	.029	3	3
UCEC	INPP4B →	-0.211	-2.321	.021	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ATM by RB1CC1 expression — UCEC

Explore this box plot interactively →