RB1CC1

Across TCGA pan-cancer cohorts, RB1CC1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RB1CC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RB1CC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RB1CC1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where RB1CC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RB1CC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.759	<.001	11	view →
LIHC	Male	II,III,IV	+1.316	<.001	9	view →
THCA	All	All	−0.416	<.001	8	view →
CHOL	All	All	+1.290	<.001	5	view →
LUSC	All	All	+0.342	.002	4	view →
LUAD	Male	All	+0.361	.030	3	view →
KICH	Male	IV	+1.156	.004	2	view →
UCEC	All	All	−0.399	.049	2	view →
LUAD	Female	II,III,IV	−0.374	.034	1	view →
COAD	Male	All	+0.367	.039	1	view →
ESCA	All	All	+0.361	.032	1	view →
BRCA	All	II,III,IV	+0.175	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RB1CC1–HNSC

Open the HNSC breakdown →