RB1CC1

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, RB1CC1 mutation is significantly associated with the RNA expression of many other genes, with 492 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RB1CC1-associated genes across cancer lineages are NPHS2, ZNF391, and TTI2. Each is linked with RB1CC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RB1CC1-to-partner and partner-to-RB1CC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by RB1CC1-low versus RB1CC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RB1CC1→partner) and Y-score (partner→RB1CC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLOOD_LymphomaNPHS2 →+0.020+3.169<.001.00832
LARGE_INTESTINEZNF391 →+0.937+3.212<.001.00632
LARGE_INTESTINETTI2 →+0.599+3.212.006.00632
LARGE_INTESTINETMEM50B →+0.623+3.212.001.00632
LARGE_INTESTINEMTNR1A →+0.420+3.212<.001.00632
LARGE_INTESTINEFBXO16 →+0.875+3.212.001.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 492 associations by consensus.

NPHS2 by RB1CC1 expression — BLOOD_Lymphoma

Box plot of NPHS2 in RB1CC1-low vs RB1CC1-high samples in BLOOD_Lymphoma.

Explore this box plot interactively →

Exploration