RB1

Across TCGA pan-cancer cohorts, RB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RB1 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RB1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where RB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.831	0.467	.013	12	view →
LUAD	OS	Median	All	0.680	1.000	.009	12	view →
HNSC	DFS	Median	IV	0.697	0.890	.021	3	view →
CCRCC	OS	Median	All	0.652	1.000	.008	2	view →
PDAC	OS	Quartile	II,III,IV	0.717	0.920	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RB1–LSCC (DFS)

Open the LSCC breakdown →