RB1

Across TCGA pan-cancer cohorts, RB1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RB1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where RB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.756	<.001	12	view →
KIRP	All	II,III,IV	+0.641	.001	11	view →
HNSC	Male	All	+0.704	<.001	9	view →
KICH	Female	II,III,IV	−2.085	<.001	8	view →
STAD	All	II,III,IV	+0.782	<.001	7	view →
CHOL	All	II,III,IV	+1.670	<.001	5	view →
LUAD	Female	All	−0.323	.008	5	view →
COAD	Male	All	+0.493	<.001	3	view →
LIHC	All	All	+0.371	.017	3	view →
ESCA	All	All	+0.952	.026	1	view →
LUSC	Female	All	−0.800	.026	1	view →
BLCA	Male	IV	+0.395	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RB1–KIRC

Open the KIRC breakdown →