RB1

Across TCGA patient cohorts, RB1 mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RB1-associated genes across cancer lineages are PCNA, Cyclin-B1, and Stathmin. Each is linked with RB1 in more than 6 cancer types. Because this analysis shows association rather than direction, both RB1-to-partner and partner-to-RB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RB1-low versus RB1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RB1→partner) and Y-score (partner→RB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCNA →	+0.283	+3.015	<.001	.020	3	7
BRCA	Cyclin-B1 →	+1.037	+3.459	<.001	.005	3	7
SKCM	Stathmin →	+0.262	+3.025	.007	.018	3	5
BRCA	MSH6 →	+0.586	+3.464	<.001	.003	3	4
BRCA	Cyclin-E2 →	+0.540	+2.591	<.001	.006	3	4
BLCA	GSK3-a-b →	+0.085	+1.519	.033	.013	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

PCNA by RB1 expression — BRCA

Explore this box plot interactively →