RB1

Across TCGA cell cohorts, RB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,458 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RB1-associated GO terms across cancer lineages are Sister chromatid biorientation, Regulation of lipid kinase activity, and Positive regulation of metaphase/anaphase transition of cell cycle. Each is linked with RB1 in more than 15 cancer types. Because this analysis shows association rather than direction, both RB1-to-partner and partner-to-RB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid biorientation grouped by RB1-low versus RB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RB1→partner) and Y-score (partner→RB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Sister chromatid biorientation →	+0.216	+1.557	<.001	<.001	2	16
OVARY	Regulation of lipid kinase activity →	+0.193	+1.408	<.001	.003	3	15
PANCREAS	Positive regulation of metaphase/anaphase transition of cell cycle →	+0.119	+0.823	<.001	<.001	3	14
URINARY_TRACT	Maintenance of sister chromatid cohesion →	+0.151	+1.633	<.001	<.001	3	14
URINARY_TRACT	Maintenance of mitotic sister chromatid cohesion →	+0.151	+1.633	<.001	<.001	3	14
OESOPHAGUS	Protein localization to chromosome, centromeric region →	+0.166	+1.148	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,458 associations by consensus.

Sister chromatid biorientation by RB1 expression — BONE

Explore this box plot interactively →