RB1

Across TCGA cell cohorts, RB1 mutation is significantly associated with the RNA expression of many other genes, with 545 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RB1-associated genes across cancer lineages are OR1L3, TCEAL5, and CLPSL1. Each is linked with RB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RB1-to-partner and partner-to-RB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by RB1-low versus RB1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RB1→partner) and Y-score (partner→RB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR1L3 →	+0.014	+3.209	<.001	.007	3	3
LUNG_SCLC	TCEAL5 →	+2.709	+1.263	<.001	<.001	3	2
URINARY_TRACT	CLPSL1 →	+0.445	+3.129	.001	.002	3	2
SOFT_TISSUE	GOLGA6L22 →	+0.012	+3.635	<.001	.007	3	2
LARGE_INTESTINE	IRGC →	+0.091	+4.035	<.001	.003	3	2
SKIN	CWH43 →	+0.025	+3.345	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 545 associations by consensus.

OR1L3 by RB1 expression — STOMACH

Explore this box plot interactively →