RB1-DT

Across TCGA pan-cancer cohorts, RB1-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RB1-DT data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RB1-DT RNA is associated with better overall survival. In most high-consensus cancer types, elevated RB1-DT expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

LUAD, UCS, and KICH are the cancer types where RB1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.885	0.712	<.001	78	view →
UCS	DFS	Tertile	All	0.484	0.118	.003	56	view →
KICH	OS	Median	III,IV	0.431	0.920	.004	37	view →
READ	OS	Median	III,IV	0.717	0.268	<.001	36	view →
HNSC	OS	Median	II,III,IV	0.701	0.803	.005	30	view →
BRCA	OS	Median	All	0.946	0.901	.003	26	view →
PAAD	DFS	Tertile	All	0.402	0.191	.006	20	view →
ESCA	OS	Median	II,III,IV	0.658	0.355	.001	17	view →
COAD	OS	Median	All	0.507	0.651	.004	13	view →
STAD	DFS	Median	IV	0.218	0.593	.041	9	view →
UCEC	OS	Median	All	0.905	0.841	.012	8	view →
GBM	OS	Quartile	All	0.295	0.612	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RB1-DT–LUAD (OS)

Open the LUAD breakdown →