RB1-DT

Across TCGA pan-cancer cohorts, RB1-DT RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RB1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RB1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types RB1-DT is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where RB1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RB1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.438	<.001	8	view →
KICH	Female	II,III,IV	−0.682	<.001	7	view →
BRCA	Female	II,III,IV	−0.254	<.001	6	view →
COAD	Male	All	+0.197	.007	6	view →
STAD	All	All	+0.237	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RB1-DT–THCA

Open the THCA breakdown →