RAX

Across TCGA patient cohorts, RAX mutation is significantly associated with the RNA expression of many other genes, with 146 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAX-associated genes across cancer lineages are SUMO2P7, SEPTIN14, and GIP. Each is linked with RAX in more than 1 cancer types. Because this analysis shows association rather than direction, both RAX-to-partner and partner-to-RAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUMO2P7 grouped by RAX-low versus RAX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAX→partner) and Y-score (partner→RAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUMO2P7 →	+0.444	+2.707	<.001	.004	3	2
UCEC	SEPTIN14 →	+0.671	+4.084	<.001	<.001	3	1
UCEC	GIP →	+0.621	+4.390	<.001	<.001	3	1
UCEC	UTP15 →	+0.540	+3.245	.006	.009	3	1
UCEC	PROP1 →	+0.286	+3.071	<.001	.003	3	1
UCEC	GJA1P1 →	+0.210	+2.881	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

SUMO2P7 by RAX expression — UCEC

Explore this box plot interactively →