RASSF4

Across TCGA pan-cancer cohorts, RASSF4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RASSF4 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RASSF4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RASSF4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, CCRCC, and GBM are the cancer types where RASSF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	1.000	0.304	.022	12	view →
CCRCC	DFS	Quartile	III,IV	0.474	0.940	.014	9	view →
GBM	OS	Quartile	All	0.482	0.814	.009	9	view →
LUAD	DFS	Median	II,III,IV	0.972	0.716	.004	5	view →
HNSC	OS	Median	All	0.943	0.992	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RASSF4–UCEC (DFS)

Open the UCEC breakdown →