RASSF4

Across TCGA pan-cancer cohorts, RASSF4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RASSF4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RASSF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RASSF4 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

KIRC, LIHC, and STAD are the cancer types where RASSF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASSF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+2.091	<.001	12	view →
LIHC	Female	II,III,IV	+1.642	<.001	7	view →
STAD	All	II,III,IV	+1.068	<.001	6	view →
BRCA	All	III,IV	−0.712	<.001	6	view →
UCEC	All	All	+0.553	.005	6	view →
HNSC	Female	All	+0.883	.004	4	view →
KICH	All	All	−0.691	.001	4	view →
LUSC	All	All	−0.448	.001	4	view →
CHOL	Female	All	+3.330	<.001	3	view →
PAAD	All	All	−1.632	.031	2	view →
KIRP	Male	All	+0.551	.043	2	view →
PRAD	All	All	−0.550	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RASSF4–KIRC

Open the KIRC breakdown →