RASSF4

Across TCGA patient cohorts, RASSF4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASSF4-associated genes across cancer lineages are eIF4E, PCNA, and c-Myc. Each is linked with RASSF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RASSF4-to-partner and partner-to-RASSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RASSF4-low versus RASSF4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASSF4→partner) and Y-score (partner→RASSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.221	+3.195	.012	.010	3	2
COAD	PCNA →	+0.319	+3.000	.009	.034	3	2
COAD	c-Myc →	-0.309	-3.161	.007	.019	3	2
UCEC	C-Raf →	+0.246	+2.700	<.001	.006	2	3
UCEC	MSH2 →	-0.252	-3.295	.010	.009	3	2
UCEC	ASNS →	+0.501	+3.169	.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by RASSF4 expression — COAD

Explore this box plot interactively →