RASSF4

Across TCGA cell cohorts, RASSF4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RASSF4-associated genes across cancer lineages are IL3, PRAMEF10, and PRAMEF17. Each is linked with RASSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASSF4-to-partner and partner-to-RASSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by RASSF4-low versus RASSF4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASSF4→partner) and Y-score (partner→RASSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL3 →	+0.052	+5.614	<.001	<.001	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	HTR3D →	+0.020	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	CCT8L2 →	+0.072	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

IL3 by RASSF4 expression — LUNG_SCLC

Explore this box plot interactively →