RASSF1

Across TCGA patient cohorts, RASSF1 mutation is significantly associated with the RNA expression of many other genes, with 1,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASSF1-associated genes across cancer lineages are TRAJ23, RNU6-505P, and RNA5SP410. Each is linked with RASSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASSF1-to-partner and partner-to-RASSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ23 grouped by RASSF1-low versus RASSF1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASSF1→partner) and Y-score (partner→RASSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	TRAJ23 →	+0.605	+5.186	<.001	.007	3	2
BLCA	RNU6-505P →	+0.665	+6.147	<.001	.002	3	2
LUSC	RNA5SP410 →	+1.120	+6.309	<.001	.001	3	2
UCEC	RNA5SP414 →	+0.446	+2.255	.004	.009	3	2
CESC	LINC02329 →	+0.064	+6.584	<.001	<.001	3	2
UCEC	RN7SL369P →	+0.152	+2.384	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,136 associations by consensus.

TRAJ23 by RASSF1 expression — LIHC

Explore this box plot interactively →