RASSF1

Across TCGA pan-cancer cohorts, RASSF1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RASSF1 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RASSF1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RASSF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

ACC, KIRC, and LGG are the cancer types where RASSF1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.236	0.659	<.001	93	view →
KIRC	DFS	Quartile	II,III,IV	0.327	0.696	<.001	54	view →
LGG	DFS	Median	All	0.619	0.845	<.001	54	view →
KICH	OS	Median	All	0.918	1.000	.006	48	view →
MESO	OS	Median	IV	0.344	0.811	.004	47	view →
LIHC	OS	Quartile	All	0.330	0.634	<.001	47	view →
HNSC	OS	Tertile	II,III,IV	0.487	0.325	.007	40	view →
LUSC	DFS	Quartile	II,III,IV	0.402	0.897	.001	30	view →
SKCM	DFS	Quartile	III,IV	0.607	0.289	.001	29	view →
THCA	OS	Tertile	II,III,IV	0.900	0.993	.011	29	view →
KIRP	OS	Tertile	II,III,IV	0.292	0.873	.005	26	view →
CHOL	DFS	Median	All	0.656	0.217	.007	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RASSF1–ACC (DFS)

Open the ACC breakdown →