RASSF1

Across TCGA patient cohorts, RASSF1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASSF1-associated genes across cancer lineages are eIF4E, Fibronectin, and MEK1. Each is linked with RASSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASSF1-to-partner and partner-to-RASSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RASSF1-low versus RASSF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASSF1→partner) and Y-score (partner→RASSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.221	+2.321	.030	.034	3	1
UCEC	Fibronectin →	-0.420	-3.584	.008	.002	3	1
UCEC	MEK1 →	+0.370	+3.169	.036	.019	3	1
UCEC	PDK1_pS241 →	+0.174	+3.169	.034	.019	3	1
UCEC	AMPK_pT172 →	+0.528	+2.472	.007	.011	3	1
UCEC	Annexin-1 →	+0.652	+2.827	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4E by RASSF1 expression — UCEC

Explore this box plot interactively →