RASL11A

Across TCGA pan-cancer cohorts, RASL11A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RASL11A data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher RASL11A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RASL11A expression acts as an unfavorable survival marker, although some lineages such as MESO and THCA show a favorable association.

UVM, MESO, and KIRP are the cancer types where RASL11A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.555	0.899	<.001	112	view →
MESO	DFS	Median	III,IV	0.510	0.292	.003	58	view →
KIRP	OS	Tertile	III,IV	0.212	0.801	.005	45	view →
UCS	OS	Tertile	III,IV	0.240	0.707	.002	42	view →
THCA	DFS	Quartile	All	0.948	0.752	<.001	37	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	33	view →
ACC	OS	Tertile	IV	0.359	0.772	.001	28	view →
CHOL	DFS	Quartile	All	0.904	0.150	<.001	27	view →
KIRC	DFS	Tertile	IV	0.740	0.465	.021	24	view →
CESC	DFS	Tertile	All	0.413	0.657	.006	24	view →
SARC	OS	Tertile	All	0.905	0.751	.007	19	view →
LUAD	DFS	Tertile	All	0.357	0.204	.004	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RASL11A–UVM (DFS)

Open the UVM breakdown →