RASL11A

Across TCGA pan-cancer cohorts, RASL11A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RASL11A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RASL11A RNA is repressed in tumor relative to normal tissue. In most cancer types RASL11A is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and THCA are the cancer types where RASL11A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASL11A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−3.427	<.001	11	view →
BLCA	Male	III,IV	−2.887	<.001	11	view →
THCA	All	IV	−1.927	<.001	11	view →
KIRC	Male	II,III,IV	−0.920	<.001	11	view →
LUAD	Male	II,III,IV	−1.668	<.001	9	view →
LUSC	All	III,IV	−2.058	<.001	8	view →
BRCA	All	II,III,IV	−1.334	<.001	8	view →
UCEC	All	All	−2.089	<.001	6	view →
COAD	All	All	−0.636	.001	4	view →
KIRP	All	All	−0.839	<.001	3	view →
LIHC	All	All	−0.475	.019	3	view →
PRAD	All	All	−0.675	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RASL11A–KICH

Open the KICH breakdown →