RASGRP2

Across TCGA patient cohorts, RASGRP2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASGRP2-associated genes across cancer lineages are ERK2, JNK2, and MEK1. Each is linked with RASGRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGRP2-to-partner and partner-to-RASGRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RASGRP2-low versus RASGRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP2→partner) and Y-score (partner→RASGRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.285	+3.247	<.001	<.001	3	2
COAD	JNK2 →	+0.245	+3.008	.010	.019	3	2
UCEC	MEK1 →	+0.277	+1.678	.048	.023	3	2
UCEC	PCNA →	+0.188	+2.115	.023	.017	3	2
UCEC	Annexin-1 →	+0.637	+2.087	.001	.005	3	2
UCEC	c-Kit →	-0.181	-2.087	.042	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ERK2 by RASGRP2 expression — UCEC

Explore this box plot interactively →