RASGRP2

Across TCGA pan-cancer cohorts, RASGRP2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RASGRP2 data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RASGRP2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RASGRP2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where RASGRP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.801	0.686	<.001	115	view →
UVM	DFS	Median	All	0.313	0.656	<.001	109	view →
SKCM	OS	Median	II,III,IV	0.411	0.215	<.001	76	view →
LUAD	OS	Median	All	0.752	0.621	<.001	57	view →
SARC	OS	Tertile	All	0.853	0.594	<.001	46	view →
CESC	OS	Tertile	All	0.870	0.717	.002	38	view →
PAAD	OS	Median	II,III,IV	0.445	0.316	.002	33	view →
LGG	OS	Median	All	0.746	0.868	<.001	33	view →
LIHC	DFS	Tertile	All	0.523	0.360	.005	22	view →
THYM	OS	Tertile	All	1.000	0.702	.003	19	view →
MESO	OS	Tertile	II,III,IV	0.299	0.538	.007	18	view →
UCS	DFS	Median	II,III,IV	0.598	0.279	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RASGRP2–HNSC (OS)

Open the HNSC breakdown →