RASGRP2

Across TCGA cell cohorts, RASGRP2 mutation is significantly associated with the RNA expression of many other genes, with 243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASGRP2-associated genes across cancer lineages are SCN2A, ZNF48, and TRIM64. Each is linked with RASGRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGRP2-to-partner and partner-to-RASGRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN2A grouped by RASGRP2-low versus RASGRP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRP2→partner) and Y-score (partner→RASGRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SCN2A →	+0.924	+3.321	<.001	.009	3	2
LARGE_INTESTINE	ZNF48 →	+0.541	+3.364	.004	.002	3	2
LUNG_SCLC	TRIM64 →	+0.012	+5.029	<.001	.006	3	1
SKIN	DEFB108B →	+0.046	+6.022	<.001	.001	3	1
SKIN	OR12D1 →	+0.006	+5.415	<.001	.004	3	1
BLOOD_Leukemia	NPTX2 →	+1.644	+3.379	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 243 associations by consensus.

SCN2A by RASGRP2 expression — BLOOD_Leukemia

Explore this box plot interactively →