RASGRF1

Across TCGA cell cohorts, RASGRF1 mutation is significantly associated with the RNA expression of many other genes, with 1,040 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASGRF1-associated genes across cancer lineages are IFNA5, CHRFAM7A, and B2M. Each is linked with RASGRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGRF1-to-partner and partner-to-RASGRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA5 grouped by RASGRF1-low versus RASGRF1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRF1→partner) and Y-score (partner→RASGRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IFNA5 →	+0.047	+4.093	<.001	.004	3	2
LARGE_INTESTINE	CHRFAM7A →	+0.595	+3.321	<.001	.002	3	2
LARGE_INTESTINE	B2M →	-1.334	-3.254	.002	.003	3	2
LARGE_INTESTINE	ACER1 →	+0.062	+2.015	.001	.001	3	2
LARGE_INTESTINE	GOLGA8H →	+0.485	+2.606	<.001	.003	3	2
LARGE_INTESTINE	ZNF8 →	+0.474	+3.321	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,040 associations by consensus.

IFNA5 by RASGRF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →