RASGRF1

Across TCGA pan-cancer cohorts, RASGRF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RASGRF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RASGRF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RASGRF1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

HNSC, THCA, and LUSC are the cancer types where RASGRF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASGRF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.368	<.001	12	view →
THCA	Male	III,IV	+2.097	<.001	10	view →
LUSC	Female	All	−3.517	<.001	9	view →
LUAD	Male	II,III,IV	−3.139	<.001	9	view →
LIHC	All	All	+0.254	<.001	6	view →
BRCA	All	All	+0.372	<.001	4	view →
COAD	All	All	+0.220	.005	3	view →
STAD	All	II,III,IV	+0.731	.021	2	view →
BLCA	Male	III,IV	+0.630	.005	2	view →
PRAD	All	All	−0.398	<.001	2	view →
CHOL	All	All	+0.395	.001	2	view →
KICH	Female	All	−0.245	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RASGRF1–HNSC

Open the HNSC breakdown →