RASGEF1C

Across TCGA cell cohorts, RASGEF1C mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RASGEF1C-associated genes across cancer lineages are CD1C, SPINK9, and MMP27. Each is linked with RASGEF1C in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGEF1C-to-partner and partner-to-RASGEF1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD1C grouped by RASGEF1C-low versus RASGEF1C-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGEF1C→partner) and Y-score (partner→RASGEF1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CD1C →	+0.032	+4.981	<.001	.008	3	1
CNS	SPINK9 →	+0.064	+5.321	<.001	.005	3	1
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.082	+5.539	<.001	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CD1C by RASGEF1C expression — CNS

Explore this box plot interactively →